Shigeru Ohta Selected Research

1- (3',4'- dihydroxybenzyl)- 1,2,3,4- tetrahydroisoquinoline

9/2014

Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.

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Shigeru Ohta Research Topics

Disease

12	Neuroblastoma 01/2016 - 03/2002
7	Parkinsonian Disorders (Parkinsonism) 09/2014 - 05/2002
6	Neoplasms (Cancer) 01/2016 - 05/2002
6	Breast Neoplasms (Breast Cancer) 08/2006 - 12/2002
5	Parkinson Disease (Parkinson's Disease) 09/2014 - 03/2002
5	Rhabdoid Tumor (Rhabdoid Tumors) 03/2014 - 09/2002
3	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 03/2017 - 01/2006
3	Infections 02/2010 - 02/2004
2	Drug-Related Side Effects and Adverse Reactions 01/2022 - 02/2015
2	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 02/2012 - 11/2011
2	Leukemia 02/2010 - 05/2002
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2004 - 05/2002
1	COVID-19 01/2023
1	Hyperuricemia 12/2022
1	Gout 12/2022
1	Cholestasis 01/2019
1	Starvation 01/2017
1	Endodermal Sinus Tumor (Endodermal Sinus Tumors) 03/2015
1	Neoplasm Metastasis (Metastasis) 03/2015
1	Hyperbilirubinemia 07/2014
1	Hyperferritinemia 07/2014
1	Hypersensitivity (Allergy) 02/2014
1	Allergic Contact Dermatitis 02/2014
1	Stroke (Strokes) 08/2012
1	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 07/2012
1	Body Weight (Weight, Body) 11/2011
1	Encephalitis (Encephalitis, Rasmussen) 09/2011
1	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 09/2011
1	Medulloblastoma 09/2011
1	Hemophilia A (Haemophilia) 01/2011
1	Hydrocephalus (Hydrocephaly) 01/2011
1	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2011
1	Prostatic Neoplasms (Prostate Cancer) 07/2010

Drug/Important Bio-Agent (IBA)

4	NeurotoxinsIBA 01/2014 - 03/2002
3	Inosine Triphosphate (ITP)IBA 03/2017 - 01/2006
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 09/2014 - 03/2002
3	1,2,3,4- tetrahydro- 1- (phenylmethyl)isoquinolineIBA 01/2014 - 02/2005
3	Estrogens (Estrogen)FDA Link 08/2005 - 03/2003
2	LigandsIBA 01/2016 - 11/2003
2	Dopamine (Intropin)FDA LinkGeneric 09/2014 - 07/2006
2	1,2,3,4-tetrahydroisoquinolineIBA 01/2014 - 01/2007
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2007 - 03/2002
2	Electron Transport Complex I (NADH-CoQ Reductase)IBA 01/2007 - 06/2004
2	Immunoglobulins (Immunoglobulin)IBA 09/2006 - 05/2002
2	Proteins (Proteins, Gene)FDA Link 09/2006 - 09/2002
2	1-methyl-1,2,3,4-tetrahydroisoquinolineIBA 07/2006 - 05/2002
1	Allopurinol (Remid)FDA LinkGeneric 12/2022
1	Felbamate (Felbatol)FDA Link 01/2022
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	Rifampin (Rifampicin)FDA LinkGeneric 01/2019
1	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 01/2019
1	Alkaline PhosphataseIBA 01/2019
1	Bile Acids and Salts (Bile Acids)IBA 01/2019
1	Ketoconazole (Nizoral)FDA LinkGeneric 01/2019
1	cepharanthineIBA 03/2017
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	NVP-TAE684IBA 01/2016
1	MidkineIBA 01/2016
1	pleiotrophin (HARP)IBA 01/2016
1	Anaplastic Lymphoma KinaseIBA 01/2016
1	Aldehyde OxidaseIBA 02/2015
1	Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA 09/2014
1	1- (3',4'- dihydroxybenzyl)- 1,2,3,4- tetrahydroisoquinolineIBA 09/2014
1	catechol (pyrocatechol)IBA 09/2014
1	BilirubinIBA 07/2014
1	Ferritins (Ferritin)IBA 07/2014
1	OligonucleotidesIBA 03/2014
1	CosmeticsIBA 02/2014
1	ParabensIBA 02/2014
1	Hormones (Hormone)IBA 08/2012
1	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 02/2012
1	Immunoglobulin A (IgA)IBA 11/2011
1	Intravenous Immunoglobulins (IVIG)FDA Link 11/2011
1	Immunoglobulin M (IgM)IBA 11/2011
1	Immunoglobulin G (IgG)IBA 11/2011
1	SteroidsIBA 09/2011
1	Acyclovir (Aciclovir)FDA LinkGeneric 09/2011
1	Rituximab (Mabthera)FDA Link 09/2011
1	Epstein-Barr virus encoded RNA 1IBA 09/2011
1	Ganciclovir (Cytovene)FDA LinkGeneric 09/2011
1	TubulinIBA 09/2010
1	Androgen Receptors (Androgen Receptor)IBA 07/2010
1	AndrogensIBA 07/2010
1	hydroxyflutamideIBA 07/2010
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 04/2010
1	Cytarabine (Cytosar-U)FDA LinkGeneric 02/2010

Therapy/Procedure

4	Drug Therapy (Chemotherapy) 09/2011 - 05/2002
2	Hematopoietic Stem Cell Transplantation 07/2012 - 12/2004
2	Radiotherapy 09/2011 - 04/2007
2	Aftercare (After-Treatment) 04/2007 - 09/2002
1	Palliative Care (Palliative Therapy) 01/2023
1	Combined Modality Therapy 03/2015
1	Cell Transplantation 11/2011
1	Nutritional Support (Artificial Feeding) 09/2011
1	Ventriculoperitoneal Shunt 01/2011
1	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2011
1	Catheters 01/2011
1	Remission Induction 02/2010
1	Therapeutics 02/2010